The advantages of the tablet dosage form are:
1. They are unit dosage form and offer the greatest capabilities of all oral dosage form for the greatest dose precision and the least content variability.
2. Cost is lowest of all oral dosage form.
3. Lighter and compact.
4. Easiest and cheapest to package and strip.
5. Easy to swallowing with least tendency for hang‐up.
6. Sustained release product is possible by enteric coating.
7. Objectionable odour and bitter taste can be masked by coating technique.
8. Suitable for large scale production.
9. Greatest chemical and microbial stability over all oral dosage form.
10. Product identification is easy and rapid requiring no additional steps when employing an embossed and/or monogrammed punch face.
Disadvantages of tablet dosage form are:
1. Difficult to swallow in case of children and unconscious patients.
2. Some drugs resist compression into dense compacts, owing to amorphous nature, low density character.
3. Drugs with poor wetting, slow dissolution properties, optimum absorption high in GIT may be difficult to formulate or manufacture as a tablet that will still provide adequate or full drug bioavailability.
4. Bitter testing drugs, drugs with an objectionable odor or drugs that are sensitive to oxygen may require encapsulation or coating. In such cases, capsule may offer the best and lowest cost.
Dietary Supplement products have a crucial impact on our lives, especially in the medical and food industries. Since Dietary Supplement is so important, let's take a look at the differences between Chinese and foreign Hard capsules products and their outlook. Here are some answers.
Here is the content list:
l The differences between Chinese and foreign Dietary Supplements.
l Prospective analysis of Dietary Supplement.
Firstly, Dietary Supplement has not yet become a legal definition in China, whereas it is a legal concept in the USA. Secondly, Dietary Supplement in China is a product set that straddles health food and general food, while Dietary Supplement in the United States is the third category of product that is different from general food and medicine. Thirdly, the ingredients of Dietary Supplement in China must be essential nutrients or biologically active substances with relatively clear constitutive relationships, whereas Dietary Supplement in the US does not have such a definition. Fourthly, the purpose of the Dietary Supplement in China is to improve the health of the body and reduce the risk of disease, whereas the purpose of Dietary Supplement in the USA is to supplement dietary ingredients. Fifthly, Health food in China has the status of healthy food and therefore can claim to assist in lowering blood lipids and eliminating melasma, while Dietary Supplements in the US cannot make such claims.
The most important uncertainties in the hazard characterization of Dietary Supplement presented by the US National Research Council arise from the following issues: firstly, if animal information is used, which toxicity endpoints should be considered, and which indicators of representation should be used. Secondly, what are the differences in bioavailability and dose-response relationships between animals and humans? Thirdly, if human information is used, what are the damaging effects of use, and what are the differences between dose-response relationships. Fourth, how information on subchronic exposures can be used to estimate the risk of lifetime exposure. Fifth, how information on non-dietary route exposures is used.
The information used to determine human effect levels for the Dietary Supplement is inadequate and we should focus on using appropriate techniques to better identify and quantify these parameters, such as the use of appropriate and sensitive exposure/effect biomarkers. In addition, ULs for most nutrients are formulated in terms of body weight, whereas RDAs can be expressed in terms of energy intake or unsaturated lipid intake, which raises the question of which indicator to use. The toxic effects of nutrient requirements and excesses vary according to the life cycle, for example during pregnancy.
Information on nutrient interactions and the different exposure settings of individuals has led to the recognition that for some Dietary Supplements a single NOAEL cannot be used alone and that further understanding of population differences in nutrient interactions may be useful in conducting risk assessments and determining appropriate ULs.
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Health food is a supplement based on vitamins, minerals, and extracts with a relatively clear structure-activity relationship, which is taken orally to supplement essential nutrients and bioactive substances to improve health and reduce the risk of disease. The following Dietary Supplement manufacturers will introduce you to the characteristics and requirements of Dietary Supplements. Here are some answers.
Here is the content list:
l What are the characteristics of Dietary Supplements?
l What requirements must a Dietary Supplement meet?
The raw materials used in Dietary Supplement are mainly taken from natural species, but there are also safe and reliable substances produced through chemical or biological technology, such as plant and animal extracts, vitamins, minerals, amino acids, etc. Generally speaking, the physical and chemical properties of the functional ingredients are relatively stable, the chemical structure is relatively clear, the mechanism of action has been scientifically proven to a certain extent, and the safety, functionality, and quality control meet the regulatory standards.
Dietary Supplement is mainly available in the form of pharmaceutical-like products in the following dosage forms: hard capsules, soft capsules, tablets, oral liquids, granules, powders, etc. The packaging forms are pre-packaged in bottles, drums (boxes), bags, and aluminum blister packs.
Immunity increases with the status of general food can follow the requirements of the "Nutritional Labelling Regulation for Food" issued by the Ministry of Health in 2008 and label the product with nutrition or nutrient function claims. Health food products approved by the health administration can only claim the specific health functions approved, and the publication of advertisements needs to be approved by the State Drug Administration. Dietary Supplement, on the other hand, can only claim to supplement (specifically) nutrients.
Firstly, Dietary Supplement containing more than three (inclusive) vitamins and minerals can only be described as a complex or multiple Dietary Supplement. The label and instructions should indicate each content, recommended intake, method of storage and precautions, etc. Thirdly, Dietary Supplements should consist of one or more vitamins or minerals in the form of tablets, capsules, tablets, or oral liquid; the daily consumption of tablets should not exceed 20 grams and the daily consumption of oral liquid should not exceed 30 ml. Fourthly, Dietary Supplements must obtain a health food approval certificate before they can be manufactured and sold. Fifthly, the excipients added to Dietary Supplements should be mainly to enhance the product's process performance or improve the taste of the product. Sixth, the raw materials and excipients in Skin care should provide their sources and quality standards; chemically synthesized Dietary Supplement raw materials should be "Hygienic Standards for the Use of Food Additives", the relevant circulars of the Ministry of Health or the Pharmacopoeia of the types of Dietary Supplement raw materials allowed to be used and comply with the corresponding provisions, otherwise, Otherwise, it should be evaluated for safety and toxicology concerning the requirements for new food resources and provide scientific proof of safe human intake.
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There is no single product category for our health food products in the USA. Most health food products can be classified as Dietary Supplement or general food with functional claims, and all of them fall within the scope of food regulation. Next, let's take a look at the scope of a Dietary Supplement in the United States and the regulatory authorities. Here are some answers.
Here is the content list:
l The scope of Dietary Supplement in the USA.
l Regulatory authority for Dietary Supplement in the United States.
A Dietary Supplement is a product (not tobacco) intended to supplement the diet and may contain one or more of the following dietary ingredients: vitamins, minerals, herbs (herbal) or other plants, amino acids, and dietary ingredients to increase the total daily intake, or a concentrate, metabolite, extract or combination of these ingredients. It may not be consumed in the form of tablets, capsules, powders, soft gels, or oral liquids; it may not be consumed as a conventional food or as the sole component of a meal diet. DSHEA also allows the use of pharmaceutical ingredients, such as approved or licensed new drugs, antibiotics, biologics, etc., provided that they have been marketed as Immunity increases or food before the relevant approval, certification, or licensing; however, if they have not been marketed as a Dietary Supplement or food before the relevant approval or certification, they may not be used as a Dietary Supplement. However, if the substance has not been marketed as a Dietary Supplement or food before the relevant approval or certification, it may not be used in Dietary Supplement.
The US Food and Drug Administration (FDA), one of the federal executive agencies of the Department of Health and Human Services (HHS), is the regulatory authority for Dietary Supplement, which is different from "conventional" foods and drugs, primarily under DSHEA, which was established in 1994. Dietary Supplements and Dietary Ingredients Manufacturers and distributors of dietary supplements and dietary ingredients are responsible for assessing the safety and labeling of their products before marketing to ensure that they meet all the requirements of DSHEA and the relevant FDA regulations. The Centre for Food Safety and Applied Nutrition (CFSAN) is responsible for the safety and labeling of the Hard capsules. The National Institutes of Health (NIH), one of the HHS divisions, focuses on scientific research and the NIH Office of Dietary Supplement (ODS) coordinates the overall management of the Dietary Supplement. The common goal of NIH and FDA is to promote public health by facilitating the translation of basic and clinical research into medical products and treatments. These agencies complement each other in their roles and functions: NIH supports and conducts biomedical and behavioral research, and FDA ensures the safety and efficacy of medical and other products. In addition, the Committee on Dietary Supplement Labelling (CDSL) examines the regulatory and Dietary Supplement claims on labels and provides recommendations on how best to provide consumers with information that is truthful, scientifically valid, and not misleading. The Commission is composed of seven members appointed by the President. The members of the committee should have expertise and experience in the manufacture, regulation, distribution, and use of Dietary Supplement. At least three of the members should have scientific training and experience to assess the health benefits of Dietary Supplement use, and one of the members should have experience in pharmacology, medical botany, traditional herbal medicine, or other science-related fields. Committee members and staff should be free from bias on Dietary Supplement issues.
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Chinese New Year, also known as Spring Festival or the Lunar New Year,
is the festival that celebrates the beginning of a new year on the traditional Chinese calendar.
Hope everything will goes well with everybody in this new year!
Omega-3 fatty acids are found in foods, such as fish and flaxseed, and in dietary supplements, such as fish oil.
The three main omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). ALA is found mainly in plant oils such as flaxseed, soybean, and canola oils. DHA and EPA are found in fish and other seafood.
ALA is an essential fatty acid, meaning that your body can’t make it, so you must get it from the foods and beverages you consume. Your body can convert some ALA into EPA and then to DHA, but only in very small amounts. Therefore, getting EPA and DHA from foods (and dietary supplements if you take them) is the only practical way to increase levels of these omega-3 fatty acids in your body.
Omega-3s are important components ofthe membranes that surround each cell in your body. DHA levels are especially high in retina (eye), brain, and sperm cells.Omega-3s also provide calories to give your body energy and have many functions in your heart, blood vessels, lungs, immune system, and endocrine system (the network of hormone-producing glands).
How much omega-3s do I need?
Experts have not established recommended amounts for omega-3 fatty acids, except for ALA. Average daily recommended amounts for ALA are listed below in grams (g). The amount you need depends on your age and sex.
Gout is a type of arthritis. It is caused by having too much of the chemical, uric acid, in your bloodstream. Uric acid is the waste product created when the body breaks down purines a type of protein found in many foods and all of your cells). Increased levels of uric acid in your blood may occur if, for example, your kidneys cannot efficiently remove it, you have a rare genetic abnormality, or because your diet and lifestyle increase the amount of uric acid that you produce. If levels of uric acid are high for prolonged periods, needle-like crystals can start to form in your tissues, resulting in swollen, painful joints.
Your diet plays an important role in both causing gout and reducing the likelihood of suffering further painful attacks of gout. If you already suffer from gout, eating a diet that is rich in purines can result in a five-fold increase in gout attacks.