The advantages of the tablet dosage form are:
1. They are unit dosage form and offer the greatest capabilities of all oral dosage form for the greatest dose precision and the least content variability.
2. Cost is lowest of all oral dosage form.
3. Lighter and compact.
4. Easiest and cheapest to package and strip.
5. Easy to swallowing with least tendency for hang‐up.
6. Sustained release product is possible by enteric coating.
7. Objectionable odour and bitter taste can be masked by coating technique.
8. Suitable for large scale production.
9. Greatest chemical and microbial stability over all oral dosage form.
10. Product identification is easy and rapid requiring no additional steps when employing an embossed and/or monogrammed punch face.
Disadvantages of tablet dosage form are:
1. Difficult to swallow in case of children and unconscious patients.
2. Some drugs resist compression into dense compacts, owing to amorphous nature, low density character.
3. Drugs with poor wetting, slow dissolution properties, optimum absorption high in GIT may be difficult to formulate or manufacture as a tablet that will still provide adequate or full drug bioavailability.
4. Bitter testing drugs, drugs with an objectionable odor or drugs that are sensitive to oxygen may require encapsulation or coating. In such cases, capsule may offer the best and lowest cost.
More and more people are choosing Fish oil as a health product, but in the process of buying it, many consumers still have many questions about how to get the real deal and good quality Fish oil. Here, we would like to introduce you to a few ways to choose Fish oil. How do we choose?
This is the list of contents：
·Look at the origin
·Selecting raw materials
·Look at the appearance
·Smell
·Look at the certification mark
·Low-temperature test
Fish that live in the northern hemisphere generally have more w-3 fatty acids in their bodies, while fish from the southern hemisphere is relatively lean. Currently, the only two areas with the best-preserved natural environment are the Lower Norwegian Sea to the Barents Sea and the Labrador Sea, which naturally produce the highest quality Fish oils. Other regions, such as Australia and New Zealand, are over-exploited due to tourism, so the quality of Fish oil has also been affected to some extent.
Small fish at the bottom of the food chain usually contains fewer contaminants, while larger fish at the top of the food chain accumulate more toxins, so the best sources of Fish oil are small fish such as sardines, rather than salmon, mackerel, seals, etc.
Good Fish oil capsules are uniform in size and free from impurities. Good quality Fish oil capsules should be on the softer side and have no coloring agents added. They are pale yellow, crystal clear and have a very good body, and are not cloudy. A soft Fish oil capsule will not get stuck in the throat and is a better experience, while those capsules that are large and hard are often difficult to swallow and even require the capsule to be broken to pour out the Fish oil before it can be taken.
It is normal for Fish oil capsules to have a slight fishy smell, but if it smells heavy and feels a little top-heavy, it means that there is a problem with the quality and it is likely to be oxidized and spoilt.
If the product has a blue cap, it means that the quality of the product and the efficacy claimed on the packaging are recognized by the state and can be purchased with confidence.
Good Fish oil with a high proportion of EPA and DHA will not condense easily and will quickly return to a liquid state at room temperature, even if it condenses into a solid-state in extremely cold conditions, whereas a Fish oil with a low proportion of EPA and DHA will take longer to return to a liquid state. Therefore, to distinguish between good and bad Fish oil, the first Fish oil to return to liquid form after condensing in the freezer is the one with the highest purity of EPA and DHA.
These are just a few suggestions on how to buy Fish oil for reference. I believe that through this small science, we all have a certain understanding of how to select Fish oil. I hope that in the future when you choose Fish oil products, you can refer to the above six suggestions and buy safe, high-quality Fish oil products to protect the health of your family and friends!
There is no single product category for our health food products in the USA. Most health food products can be classified as Dietary Supplement or general food with functional claims, and all of them fall within the scope of food regulation. Next, let's take a look at the scope of a Dietary Supplement in the United States and the regulatory authorities. Here are some answers.
Here is the content list:
l The scope of Dietary Supplement in the USA.
l Regulatory authority for Dietary Supplement in the United States.
A Dietary Supplement is a product (not tobacco) intended to supplement the diet and may contain one or more of the following dietary ingredients: vitamins, minerals, herbs (herbal) or other plants, amino acids, and dietary ingredients to increase the total daily intake, or a concentrate, metabolite, extract or combination of these ingredients. It may not be consumed in the form of tablets, capsules, powders, soft gels, or oral liquids; it may not be consumed as a conventional food or as the sole component of a meal diet. DSHEA also allows the use of pharmaceutical ingredients, such as approved or licensed new drugs, antibiotics, biologics, etc., provided that they have been marketed as Immunity increases or food before the relevant approval, certification, or licensing; however, if they have not been marketed as a Dietary Supplement or food before the relevant approval or certification, they may not be used as a Dietary Supplement. However, if the substance has not been marketed as a Dietary Supplement or food before the relevant approval or certification, it may not be used in Dietary Supplement.
The US Food and Drug Administration (FDA), one of the federal executive agencies of the Department of Health and Human Services (HHS), is the regulatory authority for Dietary Supplement, which is different from "conventional" foods and drugs, primarily under DSHEA, which was established in 1994. Dietary Supplements and Dietary Ingredients Manufacturers and distributors of dietary supplements and dietary ingredients are responsible for assessing the safety and labeling of their products before marketing to ensure that they meet all the requirements of DSHEA and the relevant FDA regulations. The Centre for Food Safety and Applied Nutrition (CFSAN) is responsible for the safety and labeling of the Hard capsules. The National Institutes of Health (NIH), one of the HHS divisions, focuses on scientific research and the NIH Office of Dietary Supplement (ODS) coordinates the overall management of the Dietary Supplement. The common goal of NIH and FDA is to promote public health by facilitating the translation of basic and clinical research into medical products and treatments. These agencies complement each other in their roles and functions: NIH supports and conducts biomedical and behavioral research, and FDA ensures the safety and efficacy of medical and other products. In addition, the Committee on Dietary Supplement Labelling (CDSL) examines the regulatory and Dietary Supplement claims on labels and provides recommendations on how best to provide consumers with information that is truthful, scientifically valid, and not misleading. The Commission is composed of seven members appointed by the President. The members of the committee should have expertise and experience in the manufacture, regulation, distribution, and use of Dietary Supplement. At least three of the members should have scientific training and experience to assess the health benefits of Dietary Supplement use, and one of the members should have experience in pharmacology, medical botany, traditional herbal medicine, or other science-related fields. Committee members and staff should be free from bias on Dietary Supplement issues.
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Dietary Supplement contains only dietary ingredients that are present in the food supply. And the food has not been chemically altered. Chemical alterations are changes in the molecular structure or composition of the ingredients through hydrolysis, distillation, altered production, or fermentation conditions. For example, the use of media containing high levels of sodium selenite can germinate garlic and fermented yeast can produce high levels of organoselenium compounds. Next, we take a look at the summary of the use of Dietary Supplement and their safety profile. Here are some answers.
Here is the content list:
l Summary of the use of Dietary Supplement.
l Demonstrate the safety of Dietary Supplements, otherwise, they will be considered adulterated products.
To a certain extent, the use of Health food has become increasingly common and has influenced the nutritional status of populations. Therefore, the interference of Dietary Supplements should be taken into account when conducting studies on the health effects of nutrients, the efficacy of drugs, and other health-related studies. The possible confounding effects of other user-related behaviors should also be taken into account when evaluating the effects of Dietary Supplements used. In the absence of data on Dietary Supplement use in developed countries, work should be carried out as soon as possible to identify the problem and consider the influencing factors to develop appropriate intervention strategies in China. In addition, the investigation of Dietary Supplements should pay attention to the unification of concepts and methods to facilitate comparison between studies so as to obtain the maximum value of research.
Those who manufacture or distribute the dietary ingredient or Dietary Supplement should provide the Secretary with information that supports their conclusion that the Dietary Supplement containing the dietary ingredient is reasonably expected to be safe, including any references to published research. In other words, if a dietary ingredient intended for use in a Dietary Supplement is not present in the same chemical form in the food supply, an explanation must be given as to why the new dietary ingredient is considered safe for use under the conditions recommended or suggested by the label. If it is uncertain whether a dietary ingredient is a "new dietary ingredient", a notification may still be submitted. Regardless of whether a premarket notification is required, manufacturers and distributors are responsible for assessing the safety of the dietary ingredient used and must ensure that Vitamins sold or distributed are not adulterated. Sales records, sales contracts, manufacturing records, commercial invoices, magazine advertisements, or sales brochures can all be used as evidence to determine whether a dietary ingredient is new.
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Dietary Supplement products have a crucial impact on our lives, especially in the medical and food industries. Since Dietary Supplement is so important, let's take a look at the differences between Chinese and foreign Hard capsules products and their outlook. Here are some answers.
Here is the content list:
l The differences between Chinese and foreign Dietary Supplements.
l Prospective analysis of Dietary Supplement.
Firstly, Dietary Supplement has not yet become a legal definition in China, whereas it is a legal concept in the USA. Secondly, Dietary Supplement in China is a product set that straddles health food and general food, while Dietary Supplement in the United States is the third category of product that is different from general food and medicine. Thirdly, the ingredients of Dietary Supplement in China must be essential nutrients or biologically active substances with relatively clear constitutive relationships, whereas Dietary Supplement in the US does not have such a definition. Fourthly, the purpose of the Dietary Supplement in China is to improve the health of the body and reduce the risk of disease, whereas the purpose of Dietary Supplement in the USA is to supplement dietary ingredients. Fifthly, Health food in China has the status of healthy food and therefore can claim to assist in lowering blood lipids and eliminating melasma, while Dietary Supplements in the US cannot make such claims.
The most important uncertainties in the hazard characterization of Dietary Supplement presented by the US National Research Council arise from the following issues: firstly, if animal information is used, which toxicity endpoints should be considered, and which indicators of representation should be used. Secondly, what are the differences in bioavailability and dose-response relationships between animals and humans? Thirdly, if human information is used, what are the damaging effects of use, and what are the differences between dose-response relationships. Fourth, how information on subchronic exposures can be used to estimate the risk of lifetime exposure. Fifth, how information on non-dietary route exposures is used.
The information used to determine human effect levels for the Dietary Supplement is inadequate and we should focus on using appropriate techniques to better identify and quantify these parameters, such as the use of appropriate and sensitive exposure/effect biomarkers. In addition, ULs for most nutrients are formulated in terms of body weight, whereas RDAs can be expressed in terms of energy intake or unsaturated lipid intake, which raises the question of which indicator to use. The toxic effects of nutrient requirements and excesses vary according to the life cycle, for example during pregnancy.
Information on nutrient interactions and the different exposure settings of individuals has led to the recognition that for some Dietary Supplements a single NOAEL cannot be used alone and that further understanding of population differences in nutrient interactions may be useful in conducting risk assessments and determining appropriate ULs.
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With the rapid development of China's health food industry, the management of its raw materials and products needs to be continuously improved to meet the growing needs of the people for a better life. The United States has the largest health food market in the world, which provides material for health food researchers and regulation-making departments in China to draw on. So, let's take a look at the industrial economy and related laws regarding Dietary Supplement in the United States. Here are some answers.
Here is the content list:
l The Dietary Supplement industry is an important part of the US economy.
l Laws relating to the Dietary Supplement in the US.
The Dietary Supplement industry is an integral part of the US economy and the industry has always been committed to a positive trade balance. It is estimated that 600 Dietary Supplement manufacturers in the United States produce approximately 4,000 products, with annual sales of at least $4 billion for these products alone. To promote health, the US government has taken legislative action to protect consumers' rights to safe Dietary Supplements and to establish a rational federal framework to replace the ad hoc patchwork of Hard capsules regulatory policies, thus amending the Federal Food, Drug, and Cosmetic Act and creating the Dietary Supplement Health and Education Act (DSHEA). The DSHEA was an important milestone in the regulation of the Dietary Supplement in the US.
In addition to the FD&C Act and DSHEA, the Nutrition Facts Labeling and Education Act of 1990, an amendment to the FD&C Act, requires that most foods must have a nutrition facts label and that the food label posted must contain a statement of nutrient content, as well as some health information to meet specific requirements. The Dietary Supplement Good Manufacturing, Packaging, Labelling and Storage Practices (CGMP), issued in 2007, covers the requirements for personnel, premises, equipment and facilities, production and process control systems (quality control, package labeling, manufacturing records, batch production records, laboratory operations, manufacturing operations, packaging and labeling operations), storage and transport, repatriation of the Immunity increases, product complaints, records, and documentation. The Food Safety Modernization Act (FSMA) of 2011 amended the FD&C Act concerning the safety aspects of the food supply, with an emphasis on improving prevention, monitoring, and response to food safety issues. The Food Safety Modernisation Act 2011 (FSMA) amends the FD&C Act regarding the safety aspects of the food supply, to improve the prevention, monitoring, and response to food safety issues so that the industry and consumers can better understand and implement the Act. Draft Guidance Document New Dietary Supplement Declarations and Related Issues, food Labelling Guidelines.
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Chinese New Year, also known as Spring Festival or the Lunar New Year,
is the festival that celebrates the beginning of a new year on the traditional Chinese calendar.
Hope everything will goes well with everybody in this new year!
